"The Scream" by Edvard Munch 1893

This famous pastel work conveys a personal experience Munch had.  He said he was walking with two friends at sunset, the sky turned blood-red, he felt a surge of sadness and stopped as his friends carried on.  The clouds were like flaming swords hanging over him.  He was seized with fear and panic as he heard a scream tear through the world around him. 
The content of this piece shares a theme of death, depression, and anxiety.  There is also a sense of suspicion and danger.  He may sense a presence, although he does not see them.  He pushes against his ears so forcefully that his face resembles a screaming skull.